Why Cynomolgus Monkey Genomic DNA Matters Liver-derived genomic DNA from cynomolgus monkeys is prized for its utility in:* Toxicology and Pharmacokinetics: Preclinical studies rely on NHP models to evaluate drug metabolism, toxicity, and off-target effects, as their liver enzymes and genetic pathways closely mirror humans.* Gene Editing and CRISPR Research: High-purity DNA supports functional genomics, enabling researchers to identify gene-disease associations or validate therapeutic targets.* Immunotherapy Development: With the rise of antibody-drug conjugates (ADCs) and cell therapies, NHP DNA aids in assessing immune responses and optimizing biologics. Industry Spotlight: Innovations in ADC TechnologyA recent breakthrough in ADC design involves branched linkers, which improve drug stability and reduce off-target toxicity. Traditional ADCs, like the HER2-targeting T-DM1, faced limitations due to systemic side effects in clinical trials. However, novel linker technologies—such as those incorporating branched structures—enhance tumor-specific payload delivery, as seen in next-generation ADCs currently under development. This innovation aligns with the growing demand for precision medicine. For example, biotech companies are now leveraging NHP-derived genomic data to refine ADC pharmacokinetics (PK) and predict human responses more accurately. The Role of NHPs in Modern Drug DiscoveryCynomolgus monkeys remain a gold standard for translational research. Their genomic DNA is particularly valuable for:* Biomarker Discovery: Identifying genetic variants linked to disease susceptibility or drug resistance.* Regulatory Compliance: Regulatory agencies like the FDA often require NHP data to approve first-in-human trials, emphasizing the need for reliable genomic resources. A biotechnology company recently highlighted that over 80% of late-stage ADC candidates now incorporate NHP-derived data during preclinical phases, underscoring the material’s critical role. Ethical and Sustainable PracticesAs the industry evolves, ethical sourcing of NHP biologicals has gained prominence. Organizations are adopting strict guidelines to ensure humane treatment and environmental sustainability, which also enhances data reproducibility. Looking AheadThe integration of multi-omics approaches (genomics, proteomics, and metabolomics) with NHP models is poised to accelerate biomarker discovery. Meanwhile, advances in synthetic biology may complement—but not yet replace—the need for primate-derived DNA in complex studies. In summary, cynomolgus monkey liver genomic DNA remains a vital tool for bridging the gap between lab research and clinical success. As the biopharma industry prioritizes precision and safety, this resource will continue to drive innovations in oncology, immunology, and beyond. https://www.creative-biolabs.com/nhp-biologicals/cynomolgus-monkey-liver-genomic-dna-987.htm
That’s us!
Established in 2021, the SPTjam was conceived out of the recognition that the northwest region lacked an annual skate jam/competition event. Despite limited experience in event planning, Mike took on the challenge of making this vision a reality, collaborating with industry connections and fellow skaters. Initially, Southport had only around 5 skaters, but since the inception of the Jams, this number has surged to approximately 25, uniting individuals who might not have otherwise crossed paths. The debut jam was held at the Southport outdoor skate park, attracting 50 skaters from the UK and beyond. The triumph of that initial gathering fuelled my determination to expand and elevate the SPTjam.
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As the event gained traction in subsequent years, drawing participants globally, we encountered obstacles like relying on brand contributions for prizes and the unpredictable UK weather at the outdoor venue. In 2023, with adverse weather looming, the decision was made to relocate the event to the indoor Junction 4 skatepark. The next year, Rampworx approached us to host the jam at their facility, a renowned skatepark founded in 1997, offering a more stable and fitting setting for our growing event.
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In 2024, we reached a noteworthy milestone with over 100 entrants across men’s, women’s, and under 17 categories, marking a level of participation not seen in many years. The event has evolved into a highly anticipated annual gathering, uniting hundreds of skaters and spectators, boosting Rampworx’s business, and nurturing a sense of camaraderie among skaters. Garnering international attention, participants from 10 countries journey to be part of the excitement. The SPTjam event is a wonderful opportunity to unite the community in various ways. On special event days, we not only bring together the rollerblading community but also welcome many other communities. It’s truly inspiring to see the strong turnout of LGBT individuals at our events, and we take pride in showcasing their community. The diversity of religions and beliefs present is also heartening, as our event provides a safe space for all LGBT individuals and religious groups to come together.
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We are actively seeking ways to foster unity among these communities and raise awareness for LGBT issues, with a particular focus on combating racial discrimination. The SPTjam events aim to create an inclusive and supportive environment that promotes physical, emotional, and social growth. It serves as a sanctuary where everyone can feel secure, connect with new people, and learn about the wonderful array of communities present, all while enjoying their favourite sport.Â